Oxycodone can cause side effects that include constipation, nausea, sedation, drowsiness and respiratory depression. Flexeril Marketed under the brand name Flexeril, cyclobenzaprine is available in the U.S. by prescription as a generic drug. Compare Cyclobenzaprine vs. Percocet, which is better for uses like: Pain, Fibromyalgia and Cramping. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Cyclobenzaprine 3.8/5 over Percocet 2.8/5 in overall satisfaction. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Keller on cyclobenzaprine and percocet: There is a potential for increased drowsiness when taking these 2 medicines together. I would advise my patients not to drive or use heavy machinery if taking these medications. Talk with your doctor about this. i take 1 10/325 norco pill with 1 mg of flexeril and for me it works! i take it for upper back pain!!! period! i personally take these 2 pills at night only because i toss and turn and has helped. Percocet and cyclobenzaprine can both cause side effects such as drowsiness and dizziness. Taking them together can enhance these side effects, especially when taking such a large quantity along with alcohol. hi there can I take cyclobenzaprine (flexril-muscle relaxer) with oxycodone? I already took 10 mg of oxycodone and didnt realize the second meds I have is a muscle relaxer.should I wait for other stuff to wear off or can I take both together? Can I take Oxycodone, xanax and zanaflex together if I spread it out by 30 minutes. I have prescriptions for each but xanax and zanaflex are taken as needed. The oxycodone is 30 mg 5 times day I have prescriptions for each but xanax and zanaflex are taken as needed. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Yep on can i take flexeril while i am taking oxycodone: Bromazepam is a benzodiazepine similar to Valium. It shouldn't have any major interaction with an antibiotic like cephalexin. I am more concerned, however, that you are even taking Bromazepam-- that's a very powerful medicine and I wonder if you really need. As far as I know they can. My doctor prescribed both for lower back pain at the same time, I doubt he would have done so if it were dangerous. I can go get my Rx for Neurontin this am & only have 1 7.5 Percocet left. Planning to take 1/2 now & 1/2 at 10am. After that I plan on using Neurontin 600mg 3-4 x's daily for w/d till I can refill the other on 3-3.